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Page 1
Did you mean m laqqan (5 results)?
Is perioperative COVID-19 really associated with worse surgical outcomes? A nationwide COVIDSurg propensity-matched analysis.
Argandykov D, Dorken-Gallastegi A, El Moheb M, Gebran A, Proaño-Zamudio JA, Bokenkamp M, Renne AM, Nepogodiev D, Bhangu A, Kaafarani HMA; COVIDSurg Collaborative. Argandykov D, et al. J Trauma Acute Care Surg. 2023 Apr 1;94(4):513-524. doi: 10.1097/TA.0000000000003859. Epub 2023 Jan 19. J Trauma Acute Care Surg. 2023. PMID: 36949053 Free PMC article.
Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells.
Alpuche-Lazcano SP, Stuible M, Akache B, Tran A, Kelly J, Hrapovic S, Robotham A, Haqqani A, Star A, Renner TM, Blouin J, Maltais JS, Cass B, Cui K, Cho JY, Wang X, Zoubchenok D, Dudani R, Duque D, McCluskie MJ, Durocher Y. Alpuche-Lazcano SP, et al. Commun Med (Lond). 2023 Aug 23;3(1):116. doi: 10.1038/s43856-023-00340-7. Commun Med (Lond). 2023. PMID: 37612423 Free PMC article.
Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer's disease therapeutic.
Kang MS, Shin M, Ottoy J, Aliaga AA, Mathotaarachchi S, Quispialaya K, Pascoal TA, Collins DL, Chakravarty MM, Mathieu A, Sandelius Å, Blennow K, Zetterberg H, Massarweh G, Soucy JP, Cuello AC, Gauthier S, Waterston M, Yoganathan N, Lessard E, Haqqani A, Rennie K, Stanimirovic D, Chakravarthy B, Rosa-Neto P. Kang MS, et al. J Cereb Blood Flow Metab. 2022 May;42(5):788-801. doi: 10.1177/0271678X211035625. Epub 2021 Aug 11. J Cereb Blood Flow Metab. 2022. PMID: 34378436 Free PMC article.
In addition, the 5-week treatment rectified the cerebrospinal fluid neurofilament light chain concentrations, resting-state functional connectivity, and hippocampal atrophy measured using magnetic resonance imaging. Finally, FC5-mFc2a-ABP (referred to as KG207-M) treatment …
In addition, the 5-week treatment rectified the cerebrospinal fluid neurofilament light chain concentrations, resting-state functional conne …
Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier.
Shin JW, An S, Kim D, Kim H, Ahn J, Eom J, You WK, Yun H, Lee B, Sung B, Jung J, Kim S, Son Y, Sung E, Lee H, Lee S, Song D, Pak Y, Sandhu JK, Haqqani AS, Stanimirovic DB, Yoo J, Kim D, Maeng S, Lee J, Lee SH. Shin JW, et al. Cell Rep Methods. 2022 Nov 21;2(11):100338. doi: 10.1016/j.crmeth.2022.100338. eCollection 2022 Nov 21. Cell Rep Methods. 2022. PMID: 36452865 Free PMC article.
Targeting insulin-like growth factor-1 receptor (IGF1R) for brain delivery of biologics.
Alata W, Yogi A, Brunette E, Delaney CE, van Faassen H, Hussack G, Iqbal U, Kemmerich K, Haqqani AS, Moreno MJ, Stanimirovic DB. Alata W, et al. FASEB J. 2022 Mar;36(3):e22208. doi: 10.1096/fj.202101644R. FASEB J. 2022. PMID: 35192204
The concentration curve for IGF1R4-mFc demonstrated a linear accumulation plateauing at approximately 400 g (~1 M), suggesting a saturable mechanism of transport. Capillary depletion and mass spectrometry analyses of brain parenchyma post-ISBP confirmed the IGF1R4-mFc brai …
The concentration curve for IGF1R4-mFc demonstrated a linear accumulation plateauing at approximately 400 g (~1 M), suggesting a satu …
Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (-)-noradrenaline.
Dashwood A, Cheesman E, Wong YW, Haqqani H, Beard N, Hay K, Spratt M, Chan W, Molenaar P. Dashwood A, et al. Pharmacol Res Perspect. 2021 May;9(3):e00760. doi: 10.1002/prp2.760. Pharmacol Res Perspect. 2021. PMID: 33929079 Free PMC article.

OM prolonged TPF and t(50%) in ventricular trabeculae (600 nM, 2 M, p < .001). OM had no significant inotropic effect but reduced time dependent deterioration in contractile strength compared to control (p < .001). ...The potency of (-)-noradrenaline (pEC(50) 6.05 0.

…

OM prolonged TPF and t(50%) in ventricular trabeculae (600 nM, 2 M, p < .001). OM had no significant inotropic effect but reduced

…
Pharmacokinetics and Pharmacodynamic Effect of a Blood-Brain Barrier-Crossing Fusion Protein Therapeutic for Alzheimer's Disease in Rat and Dog.
Lessard E, Rennie K, Haqqani A, Ling B, Whitfield J, Paradis A, Araujo J, Yoganathan N, Gillard J, Stanimirovic D, Chakravarthy B. Lessard E, et al. Pharm Res. 2022 Jul;39(7):1497-1507. doi: 10.1007/s11095-022-03285-z. Epub 2022 Jun 15. Pharm Res. 2022. PMID: 35704250 Free PMC article.
PURPOSE: We have recently demonstrated the brain-delivery of an Amyloid-ss oligomer (Asso)-binding peptide-therapeutic fused to the BBB-crossing single domain antibody FC5. The bi-functional fusion protein, FC5-mFc-ABP (KG207-M) lowered both CSF and brain Ass levels after …
PURPOSE: We have recently demonstrated the brain-delivery of an Amyloid-ss oligomer (Asso)-binding peptide-therapeutic fused to the BBB-cros …
A pilot study of depression among older people in Rawalpindi, Pakistan.
Qadir F, Haqqani S, Khalid A, Huma Z, Medhin G. Qadir F, et al. BMC Res Notes. 2014 Jun 28;7:409. doi: 10.1186/1756-0500-7-409. BMC Res Notes. 2014. PMID: 24973800 Free PMC article.
FINDINGS: Data were collected from 141 respondents. 108 were community residents (m = 57 and f = 51) and 33 were living in the care homes (m = 29 and f = 4).Prevalence of depression as assessed by Geriatric Depression Scale (GDS) among community and Care Homes (CHs) …
FINDINGS: Data were collected from 141 respondents. 108 were community residents (m = 57 and f = 51) and 33 were living in the care h …
11 results